Tuesday 17 July 2012

What's Next for Venture Capital? | Pham Capital






What?s Next in Social Media






Why Managers Fail Their Teams ? And What To Do About It






Three Ways to Harness the Power of Your Intuition

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Are we in the midst of a bubble? And what might that mean for VCs? (Image credit: Getty Images via @daylife)

The number of venture capital funds has declined precipitously ? it?s down nearly 50% from its peak, says David Brophy, venture capital expert and Associate Professor of Finance at the University of Michigan?s Ross School of Business ? and deals have been slow this year. Says Brophy, ?Partners are pulling back because they don?t trust the future ? nobody does the moment ? and venture capital is a big bet on the future.? So, with Facebook?s ill-fated IPO, does that mean another dot-com bubble is about to burst?

Brophy does see similarities to the hype of the 1990s. When it comes to social media, ?we haven?t had what you might think of as ?proof of concept? or sustainability,? he says. ?Can they sustain [the growth]? We have just enough clues saying maybe they can?t? When you look back at the dot-com bubble, some very good companies sustained themselves. If you can hang on to provide something useful, your company can take its place in the economy. But do we need 50,000 companies, each one trying to do a little piece? I don?t know that it will burst, but just like venture funds, the number went up, and now it?s coming down.?

In the 1990s, says Brophy, it was relatively easy to make money during the boom times of rising stock market valuations. Since 2000, however, ?the only way to make money is by increasing cash flow and profitability of your portfolio companies, and that takes hard work and understanding the business.? The upshot? The only people who will be able to make money in a flat market are experts who bring unique operational skills ? as well as money ? to the table.

With venture capitalists forced to raise the bar, Brophy insists that entrepreneurs must follow suit. ?I think we need smarter entrepreneurs,? he says. ?The venture capitalist looks at 2000 business plans or opportunities in a year, and invests in five or six, or whatever the number might be. The entrepreneur may do it once in his or her life, and in general they?re dumb as a bag of hammers when it comes to the process. It?s a competitive country, and an economy in which competition is highly valued. If you?ve got the goods but don?t know the real value, stay tuned for someone to liberate that value from you. Entrepreneurs need to learn about the process so they?re not taken to the cleaners.?

Brophy also believes that universities ? inspired by the example of MIT and Stanford ? are poised to kick it up a notch when it comes to commercializing their research. ?The average science or engineering professor fears a rush to commercialize ? that there will be a race for Lamborghinis rather than a race to discover the cure for cancer,? he says. But commercialization isn?t a detour from the fundamental premise of universities, says Brophy ? it?s actually a return to their roots. ?It goes right back to the basis of these land-grant universities,? he says, ?to build better plows, shovels, and picks and the tools of the day. Part of the mission of universities is still that ? but now it?s not shovels and picks, it?s [silicon] chips.?

It?s harder for companies ? and the VCs that back them ? to thrive in today?s competitive environment. But that challenge may lead to sharper skills, better investments, and new innovation that benefits us all. What do you see on the horizon for venture capital in the next 1-2 years?

Dorie Clark is CEO of Clark Strategic Communications and the author of the forthcoming Reinventing You: Define Your Brand, Imagine Your Future (Harvard Business Review Press, 2013). She is a strategy consultant who has worked with clients including Google, Yale University, and the Ford Foundation. Listen to her podcasts or follow her on Twitter.

Article source: http://www.forbes.com/sites/dorieclark/2012/07/16/whats-next-for-venture-capital/

Source: http://phamcapital.com/?p=1259

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ScienceDaily: Biochemistry News

ScienceDaily: Biochemistry Newshttp://www.sciencedaily.com/news/matter_energy/biochemistry/ Read the latest research in biochemistry -- protein structure and function, RNA and DNA, enzymes and biosynthesis and more biochemistry news.en-usMon, 16 Jul 2012 10:01:08 EDTMon, 16 Jul 2012 10:01:08 EDT60ScienceDaily: Biochemistry Newshttp://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/matter_energy/biochemistry/ For more science articles, visit ScienceDaily.Elegant delivery: Sophisticated technique for delivering multiple cancer treatments may solve frustrating hurdle for combinatorial drug therapieshttp://www.sciencedaily.com/releases/2012/07/120715141402.htm Researchers have developed a novel system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to counter cancer's defensive secretions, resulting in a powerful therapy that, in mice, delayed tumor growth, sent tumors into remission and dramatically increased survival rates.Sun, 15 Jul 2012 14:14:14 EDThttp://www.sciencedaily.com/releases/2012/07/120715141402.htmAdvanced drug testing method detects 'spice' drugshttp://www.sciencedaily.com/releases/2012/07/120712224551.htm A new method of drug testing makes it possible to detect a wider range of synthetically-produced ?designer? drugs.Thu, 12 Jul 2012 22:45:45 EDThttp://www.sciencedaily.com/releases/2012/07/120712224551.htmLarge, medically important class of proteins starts to yield its secretshttp://www.sciencedaily.com/releases/2012/07/120712162710.htm New research illuminates a large and medically important family of proteins called G protein-coupled receptors (GPCRs).Thu, 12 Jul 2012 16:27:27 EDThttp://www.sciencedaily.com/releases/2012/07/120712162710.htmHighest resolution ever for human proteinhttp://www.sciencedaily.com/releases/2012/07/120712141816.htm Never has a crystal structure of a human protein molecule in a cell wall been so crystal clear. Researchers have achieved the most detailed crystal structure ever of a target protein for medicines.Thu, 12 Jul 2012 14:18:18 EDThttp://www.sciencedaily.com/releases/2012/07/120712141816.htmPlatinum is wrong stuff for fuel cells because it wastes energy, expert sayshttp://www.sciencedaily.com/releases/2012/07/120712111746.htm Fuel cells are inefficient because the catalyst most commonly used to convert chemical energy to electricity is made of the wrong material, a researcher argues. During the oxygen reduction reaction, intermediate molecules bond too tightly or too loosely to platinum, slowing the reaction and causing a drop in voltage.Thu, 12 Jul 2012 11:17:17 EDThttp://www.sciencedaily.com/releases/2012/07/120712111746.htmBlue-fluorescent molecular nanocapsules created by simple mixing 'green-environmentally friendly' metal ions and bent organic blockshttp://www.sciencedaily.com/releases/2012/07/120712111634.htm New fluorescent molecular nanocapsules have potential applications as sensors, displays, and drug delivery systems (DDS).Thu, 12 Jul 2012 11:16:16 EDThttp://www.sciencedaily.com/releases/2012/07/120712111634.htmNew technique identifies cellular 'Needle in a haystack'http://www.sciencedaily.com/releases/2012/07/120711111403.htm Rare cells can be identified within mixed cell populations with near perfect accuracy using a new detection technique. This technique may facilitate cancer diagnosis, which often relies on the detection of rare cancerous cells in tiny amounts of biopsy tissue or fluid.Wed, 11 Jul 2012 11:14:14 EDThttp://www.sciencedaily.com/releases/2012/07/120711111403.htmWaste to watts: Improving microbial fuel cellshttp://www.sciencedaily.com/releases/2012/07/120710133100.htm Some of the planet's tiniest inhabitants may help address two of society's biggest environmental challenges: How to deal with the vast quantities of organic waste produced and where to find clean, renewable energy. Anode respiring bacteria generate useful energy in a device known as a microbial fuel cell.Tue, 10 Jul 2012 13:31:31 EDThttp://www.sciencedaily.com/releases/2012/07/120710133100.htmNew insights into how the most iconic reaction in organic chemistry really workshttp://www.sciencedaily.com/releases/2012/07/120709155421.htm The Diels-Alder reaction is the most iconic organic chemistry reaction. Scientists now report on exactly how this chemical reaction, discovered in 1928, occurs.Mon, 09 Jul 2012 15:54:54 EDThttp://www.sciencedaily.com/releases/2012/07/120709155421.htmLipid helps cells find their way by keeping their 'antennae' uphttp://www.sciencedaily.com/releases/2012/07/120709121624.htm A lipid that helps lotion soften the skin also helps cells find and stay in the right location in the body by ensuring they keep their "antennae" up, scientists report.Mon, 09 Jul 2012 12:16:16 EDThttp://www.sciencedaily.com/releases/2012/07/120709121624.htm'Fingerprinting' nanoscale objects and viruseshttp://www.sciencedaily.com/releases/2012/07/120709093046.htm Scientists have found a way of effectively identifying nanoscale objects and viruses that could offer a breakthrough for biomedical diagnostics, environmental protection and nano-electronics.Mon, 09 Jul 2012 09:30:30 EDThttp://www.sciencedaily.com/releases/2012/07/120709093046.htmNew avenue to better medicines: Metal-peptide complexeshttp://www.sciencedaily.com/releases/2012/07/120709092558.htm Scientists have used metal complexes to modify peptide hormones. They report for the first time on the three-dimensional structure of the resulting metal-peptide compounds. "With this work, we have laid the molecular foundation for the development of better medicines" says one of the researchers. The team examined hormones that influence the sensation of pain and tumour growth.Mon, 09 Jul 2012 09:25:25 EDThttp://www.sciencedaily.com/releases/2012/07/120709092558.htmAqueous iron interacts as strong as solid ironhttp://www.sciencedaily.com/releases/2012/07/120706164205.htm Scientists have applied a new method -- "inverse Partial Fluorescence Yield" (iPFY) on micro-jets -- which will enable them to probe the electronic structure of liquids free of sample damages. The experiments are performed in vacuum conditions at the LiXEdrom experimental chamber, where a fluid stream of micrometer diameter is moving freely through vacuum and is continuously irradiated with X-ray radiation.Fri, 06 Jul 2012 16:42:42 EDThttp://www.sciencedaily.com/releases/2012/07/120706164205.htmFirst direct evidence that elemental fluorine occurs in naturehttp://www.sciencedaily.com/releases/2012/07/120705172050.htm Fluorine is the most reactive chemical element. Until now the accepted scientific doctrine was, that therefore it cannot exist in nature in its elemental form. A team of chemists has now, for the first time, successfully identified natural elemental fluorine in a special fluorite, the "fetid fluorite" or "antozonite."Thu, 05 Jul 2012 17:20:20 EDThttp://www.sciencedaily.com/releases/2012/07/120705172050.htmRobot vision: Muscle-like action allows camera to mimic eye movementhttp://www.sciencedaily.com/releases/2012/07/120705144407.htm Using piezoelectric materials, researchers have replicated the muscle motion of the human eye to control camera systems in a way designed to improve the operation of robots. This new muscle-like action could help make robotic tools safer and more effective for MRI-guided surgery and robotic rehabilitation.Thu, 05 Jul 2012 14:44:44 EDThttp://www.sciencedaily.com/releases/2012/07/120705144407.htmPrintable, electrically conductive gel with unprecedented electrical performance synthesizedhttp://www.sciencedaily.com/releases/2012/07/120704182543.htm Researchers have invented an electrically conductive gel that is quick and easy to make, can be patterned onto surfaces with an inkjet printer and demonstrates unprecedented electrical performance.Wed, 04 Jul 2012 18:25:25 EDThttp://www.sciencedaily.com/releases/2012/07/120704182543.htmCalcium carbonate templates for drug deliveryhttp://www.sciencedaily.com/releases/2012/07/120704124057.htm The fast and targeted delivery of drugs could soon be made easier. Microcontainers for medical substances can be produced in different sizes using calcium carbonate microspheres as templates, new research shows.Wed, 04 Jul 2012 12:40:40 EDThttp://www.sciencedaily.com/releases/2012/07/120704124057.htmNatural plant protein converted into drug-delivery vehicleshttp://www.sciencedaily.com/releases/2012/07/120703200546.htm Finding biocompatible carriers that can get drugs to their targets in the body involves significant challenges. Researchers have now shown a new approach for making vesicles and fine-tuning their shapes. By starting with a protein that is found in sunflower seeds, they used genetic engineering to make a variety of protein molecules that assemble into vesicles and other useful structures.Tue, 03 Jul 2012 20:05:05 EDThttp://www.sciencedaily.com/releases/2012/07/120703200546.htmBugs inspire better X-rays: Nanostructures modeled like moth eyes may boost medical imaginghttp://www.sciencedaily.com/releases/2012/07/120703162622.htm Using the compound eyes of the humble moth as their inspiration, physicists have developed new nanoscale materials that could someday reduce the radiation dosages received by patients getting X-rayed, while improving the resolution of the resulting images.Tue, 03 Jul 2012 16:26:26 EDThttp://www.sciencedaily.com/releases/2012/07/120703162622.htmScientists Unlock Some Key Secrets of Photosynthesishttp://www.sciencedaily.com/releases/2012/07/120702192425.htm New research is seeking to detail the individual steps of highly efficient reactions that convert sunlight into chemical energy within plants and bacteria.Mon, 02 Jul 2012 19:24:24 EDThttp://www.sciencedaily.com/releases/2012/07/120702192425.htm'Trophy molecule' breakthrough may result in cleaner, cooler nuclear energyhttp://www.sciencedaily.com/releases/2012/07/120702133535.htm Experts have created a stable version of a ?trophy molecule? that has eluded scientists for decades. They have prepared a terminal uranium nitride compound which is stable at room temperature and can be stored in jars in crystallized or powder form. The breakthrough could have future implications for the nuclear energy industry ? uranium nitride materials may potentially offer a viable alternative to the current mixed oxide nuclear fuels used in reactors since nitrides exhibit superior high densities, melting points, and thermal conductivities and the process the scientists used to make the compound could offer a cleaner, low temperature route than methods currently used.Mon, 02 Jul 2012 13:35:35 EDThttp://www.sciencedaily.com/releases/2012/07/120702133535.htmInspired by nature: Paints and coatings containing bactericidal agent nanoparticles combat marine foulinghttp://www.sciencedaily.com/releases/2012/07/120702133531.htm Scientists have discovered that tiny vanadium pentoxide nanoparticles can inhibit the growth of barnacles, bacteria, and algae on surfaces in contact with water, such as ship hulls, sea buoys, or offshore platforms. Their experiments showed that steel plates to which a coating containing dispersed vanadium pentoxide particles had been applied could be exposed to seawater for weeks without the formation of deposits of barnacles, bacteria, and algae.Mon, 02 Jul 2012 13:35:35 EDThttp://www.sciencedaily.com/releases/2012/07/120702133531.htmPrinting living tissues: 3-D printed vascular networks made of sugarhttp://www.sciencedaily.com/releases/2012/07/120701191617.htm New advances in tissue engineering could one day make a replacement liver from a patient's cells, or animal muscle tissue that could be cut into steaks. One problem with making 3-D tissue structures, however, is keeping the interior cells from suffocating. Now, researchers have developed an innovative solution: they've shown that 3-D printed templates of filament networks can be used to rapidly create vasculature and improve the function of engineered living tissues.Sun, 01 Jul 2012 19:16:16 EDThttp://www.sciencedaily.com/releases/2012/07/120701191617.htmStealthy microscopy method visualizes E. coli sub-cellular structure in 3-Dhttp://www.sciencedaily.com/releases/2012/06/120629142611.htm A sub-cellular world has been opened up for scientists to study E. coli and other tissues in new ways, thanks to a microscopy method that stealthily provides 3-D, high-quality images of the internal structure of cells without disturbing the specimen.Fri, 29 Jun 2012 14:26:26 EDThttp://www.sciencedaily.com/releases/2012/06/120629142611.htmProgrammable DNA scissors found for bacterial immune systemhttp://www.sciencedaily.com/releases/2012/06/120628193020.htm Scientists have discovered a programmable RNA complex in the bacterial immune system that guides the cleaving of DNA at targeted sites. This discovery opens a new door to genome editing with implications for the green chemistry microbial-based production of advanced biofuels, therapeutic drugs and other valuable chemical products.Thu, 28 Jun 2012 19:30:30 EDThttp://www.sciencedaily.com/releases/2012/06/120628193020.htmStudy on fungi helps explain coal formation and may advance future biofuels productionhttp://www.sciencedaily.com/releases/2012/06/120628181723.htm The evolution of white rot fungi might have helped bring an end to the geologic period characterized by the formation of large coal deposits, and may help lay the groundwork for the future production of biofuels.Thu, 28 Jun 2012 18:17:17 EDThttp://www.sciencedaily.com/releases/2012/06/120628181723.htmHow an ancestral fungus may have influenced coal formationhttp://www.sciencedaily.com/releases/2012/06/120628181721.htm The fossilized remains of plants that lived from around 360 to 300 million years ago, coal generated nearly half of the roughly four trillion kilowatt-hours of electricity consumed in the United States in 2010. An international team of scientists proposes that the evolution of fungi capable of breaking down the polymer lignin in plants may have played a key role in ending the development of coal deposits, contributing to the end of the Carboniferous period.Thu, 28 Jun 2012 18:17:17 EDThttp://www.sciencedaily.com/releases/2012/06/120628181721.htmNot-so-precious: Stripping gold from AFM probes allows better measurement of picoscale forceshttp://www.sciencedaily.com/releases/2012/06/120628164639.htm Researchers found that removing an AFM probe's gold coating -- until now considered helpful -- greatly improved force measurements performed in a liquid, the medium favored for biophysical studies such as stretching DNA or unfolding proteins.Thu, 28 Jun 2012 16:46:46 EDThttp://www.sciencedaily.com/releases/2012/06/120628164639.htmPhotosynthesis re-wired: Chemists use nanowires to power photosynthesis-like processhttp://www.sciencedaily.com/releases/2012/06/120628145741.htm Chemists have developed a process that closely resembles photosynthesis and proved capable of synthesizing compounds found in the pain-killers ibuprofen and naproxen.Thu, 28 Jun 2012 14:57:57 EDThttp://www.sciencedaily.com/releases/2012/06/120628145741.htmAcoustic tweezers capture and manipulate tiny creatures with ultrasoundhttp://www.sciencedaily.com/releases/2012/06/120628145508.htm Bioengineers and biochemists are using a miniaturized ultrasound device to capture and manipulate biological materials, such as the tiny roundworm, C. elegans.Thu, 28 Jun 2012 14:55:55 EDThttp://www.sciencedaily.com/releases/2012/06/120628145508.htmResearchers delve into airborne particulateshttp://www.sciencedaily.com/releases/2012/06/120627132116.htm Scientists have peered into the makeup of complex airborne particulate matter so small that it can be transported into human lungs -- usually without a trace.Wed, 27 Jun 2012 13:21:21 EDThttp://www.sciencedaily.com/releases/2012/06/120627132116.htmScientists measure soot particles in flighthttp://www.sciencedaily.com/releases/2012/06/120627132049.htm For the first time, air-polluting soot particles have been imaged in flight down to nanometer resolution. Pioneering a new technique scientists snapped the most detailed images yet of airborne aerosols.Wed, 27 Jun 2012 13:20:20 EDThttp://www.sciencedaily.com/releases/2012/06/120627132049.htmEasier way to make new drug compoundshttp://www.sciencedaily.com/releases/2012/06/120627131951.htm Scientists have developed a powerful new technique for manipulating the building-block molecules of organic chemistry. The technique enables chemists to add new functional molecules to previously hard-to-reach positions on existing compounds?making it easier for them to generate new drugs and other organic chemicals.Wed, 27 Jun 2012 13:19:19 EDThttp://www.sciencedaily.com/releases/2012/06/120627131951.htmA step toward minute factories that produce medicine inside the bodyhttp://www.sciencedaily.com/releases/2012/06/120627103350.htm Scientists are reporting an advance toward treating disease with minute capsules containing not drugs -- but the DNA and other biological machinery for making the drug. They describe engineering micro- and nano-sized capsules that contain the genetically coded instructions, plus the read-out gear and assembly line for protein synthesis that can be switched on with an external signal.Wed, 27 Jun 2012 10:33:33 EDThttp://www.sciencedaily.com/releases/2012/06/120627103350.htmNew technique controls crystalline structure of titanium dioxidehttp://www.sciencedaily.com/releases/2012/06/120627103310.htm Researchers have developed a new technique for controlling the crystalline structure of titanium dioxide at room temperature. The development should make titanium dioxide more efficient in a range of applications, including photovoltaic cells, hydrogen production, antimicrobial coatings, smart sensors and optical communication technologies.Wed, 27 Jun 2012 10:33:33 EDThttp://www.sciencedaily.com/releases/2012/06/120627103310.htmPositive at last: A pure phosphorus cationhttp://www.sciencedaily.com/releases/2012/06/120627092012.htm Ever since Hennig Brand's discovery in 1669, elementary phosphorus has fascinated chemists around the world. It is industrially produced by the ton and its compounds have numerous applications in materials science and the life sciences. The main known forms of the element are white, red, and black phosphorus. Chemists have now succeeded in creating a positively charged pure phosphorus compound.Wed, 27 Jun 2012 09:20:20 EDThttp://www.sciencedaily.com/releases/2012/06/120627092012.htmSeeing inside tissue for no-cut surgeries: Researchers develop technique to focus light inside biological tissuehttp://www.sciencedaily.com/releases/2012/06/120626114322.htm Imagine if doctors could perform surgery without ever having to cut through your skin. Or if they could diagnose cancer by seeing tumors inside the body with a procedure that is as simple as an ultrasound. Thanks to a new technique, all of that may be possible in the not-so-distant future.Tue, 26 Jun 2012 11:43:43 EDThttp://www.sciencedaily.com/releases/2012/06/120626114322.htmBiological switch paves way for improved biofuel productionhttp://www.sciencedaily.com/releases/2012/06/120625160403.htm A mechanism that controls the way organisms breathe or photosynthesize has been discovered by scientists. The research could pave the way for improved biofuel production.Mon, 25 Jun 2012 16:04:04 EDThttp://www.sciencedaily.com/releases/2012/06/120625160403.htmNano-sandwich technique slims down solar cells, improves efficiencyhttp://www.sciencedaily.com/releases/2012/06/120625125803.htm Researchers have found a way to create much slimmer thin-film solar cells without sacrificing the cells' ability to absorb solar energy. Making the cells thinner should significantly decrease manufacturing costs for the technology.Mon, 25 Jun 2012 12:58:58 EDThttp://www.sciencedaily.com/releases/2012/06/120625125803.htmSpeeding up bone growth by manipulating stem cellshttp://www.sciencedaily.com/releases/2012/06/120625100915.htm Differentiation of stem cells into bone nodules is greatly accelerated by nanomolecular scaffolds.Mon, 25 Jun 2012 10:09:09 EDThttp://www.sciencedaily.com/releases/2012/06/120625100915.htmNew technique allows simulation of noncrystalline materialshttp://www.sciencedaily.com/releases/2012/06/120623094310.htm Scientists have found a new mathematical approach to simulating the electronic behavior of noncrystalline materials, which may eventually play an important part in new devices including solar cells, organic LED lights and printable, flexible electronic circuits.Sat, 23 Jun 2012 09:43:43 EDThttp://www.sciencedaily.com/releases/2012/06/120623094310.htmOxygen 'sensor' may shut down DNA transcriptionhttp://www.sciencedaily.com/releases/2012/06/120619092935.htm A key component found in an ancient anaerobic microorganism may serve as a sensor to detect potentially fatal oxygen, researchers have found. This helps researchers learn more about the function of these components, called iron-sulfur clusters, which occur in different parts of cells in all living creatures.Tue, 19 Jun 2012 09:29:29 EDThttp://www.sciencedaily.com/releases/2012/06/120619092935.htmChemists use nanopores to detect DNA damagehttp://www.sciencedaily.com/releases/2012/06/120618153427.htm Scientists are racing to sequence DNA faster and cheaper than ever by passing strands of the genetic material through molecule-sized pores. Now, scientists have adapted this ?nanopore? method to find DNA damage that can lead to mutations and disease.Mon, 18 Jun 2012 15:34:34 EDThttp://www.sciencedaily.com/releases/2012/06/120618153427.htmCarbon is key for getting algae to pump out more oilhttp://www.sciencedaily.com/releases/2012/06/120618111830.htm Overturning two long-held misconceptions about oil production in algae, scientists show that ramping up the microbes' overall metabolism by feeding them more carbon increases oil production as the organisms continue to grow. The findings may point to new ways to turn photosynthetic green algae into tiny "green factories" for producing raw materials for alternative fuels.Mon, 18 Jun 2012 11:18:18 EDThttp://www.sciencedaily.com/releases/2012/06/120618111830.htmIonic liquid improves speed and efficiency of hydrogen-producing catalysthttp://www.sciencedaily.com/releases/2012/06/120616145535.htm The design of a nature-inspired material that can make energy-storing hydrogen gas has gone holistic. Usually, tweaking the design of this particular catalyst -- a work in progress for cheaper, better fuel cells -- results in either faster or more energy efficient production but not both. Now, researchers have found a condition that creates hydrogen faster without a loss in efficiency.Sat, 16 Jun 2012 14:55:55 EDThttp://www.sciencedaily.com/releases/2012/06/120616145535.htmNanoparticles hold promise to improve blood cancer treatmenthttp://www.sciencedaily.com/releases/2012/06/120615204741.htm Researchers have engineered nanoparticles that show great promise for the treatment of multiple myeloma (MM), an incurable cancer of the plasma cells in bone marrow.Fri, 15 Jun 2012 20:47:47 EDThttp://www.sciencedaily.com/releases/2012/06/120615204741.htmImproving high-tech medical scannershttp://www.sciencedaily.com/releases/2012/06/120613153331.htm A powerful color-based imaging technique is making the jump from remote sensing to the operating room. Scientists are working to ensure it performs as well when spotting cancer cells in the body as it does with oil spills in the ocean.Wed, 13 Jun 2012 15:33:33 EDThttp://www.sciencedaily.com/releases/2012/06/120613153331.htmScientists synthesize first genetically evolved semiconductor materialhttp://www.sciencedaily.com/releases/2012/06/120613133341.htm In the not-too-distant future, scientists may be able to use DNA to grow their own specialized materials, thanks to the concept of directed evolution. Scientists have, for the first time, used genetic engineering and molecular evolution to develop the enzymatic synthesis of a semiconductor.Wed, 13 Jun 2012 13:33:33 EDThttp://www.sciencedaily.com/releases/2012/06/120613133341.htmNew energy source for future medical implants: Sugarhttp://www.sciencedaily.com/releases/2012/06/120613133150.htm An implantable fuel cell could power neural prosthetics that help patients regain control of limbs. Engineers have developed a fuel cell that runs on the same sugar that powers human cells: glucose. This glucose fuel cell could be used to drive highly efficient brain implants of the future, which could help paralyzed patients move their arms and legs again.Wed, 13 Jun 2012 13:31:31 EDThttp://www.sciencedaily.com/releases/2012/06/120613133150.htmLittle mighty creature of the ocean inspires strong new material for medical implants and armourhttp://www.sciencedaily.com/releases/2012/06/120613102130.htm A scientist may be onto an ocean of discovery because of his research into a little sea creature called the mantis shrimp. The research is likely to lead to making ceramics -- today's preferred material for medical implants and military body armour -- many times stronger. The mantis shrimp's can shatter aquarium glass and crab shells alike.Wed, 13 Jun 2012 10:21:21 EDThttp://www.sciencedaily.com/releases/2012/06/120613102130.htmProtein residues kiss, don't tell: Genomes reveal contacts, scientists refine methods for protein-folding predictionhttp://www.sciencedaily.com/releases/2012/06/120612145139.htm Researchers have created a computational tool to help predict how proteins fold by finding amino acid pairs that are distant in sequence but change together. Protein interactions offer clues to the treatment of disease, including cancer.Tue, 12 Jun 2012 14:51:51 EDThttp://www.sciencedaily.com/releases/2012/06/120612145139.htmPotential carbon capture role for new CO2-absorbing materialhttp://www.sciencedaily.com/releases/2012/06/120612101458.htm A novel porous material that has unique carbon dioxide retention properties has just been developed.Tue, 12 Jun 2012 10:14:14 EDThttp://www.sciencedaily.com/releases/2012/06/120612101458.htmWorkings behind promising inexpensive catalyst revealedhttp://www.sciencedaily.com/releases/2012/06/120611193636.htm A newly developed carbon nanotube material could help lower the cost of fuel cells, catalytic converters and similar energy-related technologies by delivering a substitute for expensive platinum catalysts.Mon, 11 Jun 2012 19:36:36 EDThttp://www.sciencedaily.com/releases/2012/06/120611193636.htmNanoparticles in polluted air, smoke & nanotechnology products have serious impact on healthhttp://www.sciencedaily.com/releases/2012/06/120611105311.htm New groundbreaking research has found that exposure to nanoparticles can have a serious impact on health, linking it to rheumatoid arthritis and the development of other serious autoimmune diseases. The findings have health and safety implications for the manufacture, use and ultimate disposal of nanotechnology products and materials. They also identified new cellular targets for the development of potential drug therapies in combating the development of autoimmune diseases.Mon, 11 Jun 2012 10:53:53 EDThttp://www.sciencedaily.com/releases/2012/06/120611105311.htmA SMART(er) way to track influenzahttp://www.sciencedaily.com/releases/2012/06/120611092345.htm Researchers have created a reliable and fast flu-detection test that can be carried in a first-aid kit. The novel prototype device isolates influenza RNA using a combination of magnetics and microfluidics, then amplifies and detects probes bound to the RNA. The technology could lead to real-time tracking of influenza.Mon, 11 Jun 2012 09:23:23 EDThttp://www.sciencedaily.com/releases/2012/06/120611092345.htmResearchers watch tiny living machines self-assemblehttp://www.sciencedaily.com/releases/2012/06/120610151304.htm Enabling bioengineers to design new molecular machines for nanotechnology applications is one of the possible outcomes of a new study. Scientists have developed a new approach to visualize how proteins assemble, which may also significantly aid our understanding of diseases such as Alzheimer's and Parkinson's, which are caused by errors in assembly.Sun, 10 Jun 2012 15:13:13 EDThttp://www.sciencedaily.com/releases/2012/06/120610151304.htmPhotosynthesis: A new way of looking at photosystem IIhttp://www.sciencedaily.com/releases/2012/06/120606155808.htm Using ultrafast, intensely bright pulses of X-rays scientists have obtained the first ever images at room temperature of photosystem II, a protein complex critical for photosynthesis and future artificial photosynthetic systems.Wed, 06 Jun 2012 15:58:58 EDThttp://www.sciencedaily.com/releases/2012/06/120606155808.htm1 million billion billion billion billion billion billion: Number of undiscovered drugshttp://www.sciencedaily.com/releases/2012/06/120606132316.htm A new voyage into "chemical space" ? occupied not by stars and planets but substances that could become useful in everyday life ? has concluded that scientists have synthesized barely one tenth of one percent of potential medicines. The report estimates that the actual number of these so-called "small molecules" could be one novemdecillion (that's one with 60 zeroes), more than some estimates of the number of stars in the universe.Wed, 06 Jun 2012 13:23:23 EDThttp://www.sciencedaily.com/releases/2012/06/120606132316.htmHalogen bonding helps design new drugshttp://www.sciencedaily.com/releases/2012/06/120605121639.htm Halogens particularly chlorine, bromine, and iodine ? have a unique quality which allows them to positively influence the interaction between molecules. This ?halogen bonding? has been employed in the area of materials science for some time, but is only now finding applications in the life sciences.Tue, 05 Jun 2012 12:16:16 EDThttp://www.sciencedaily.com/releases/2012/06/120605121639.htmFaster, more sensitive photodetector created by tricking graphenehttp://www.sciencedaily.com/releases/2012/06/120605102842.htm Researchers have developed a highly sensitive detector of infrared light that can be used in applications ranging from detection of chemical and biochemical weapons from a distance and better airport body scanners to chemical analysis in the laboratory and studying the structure of the universe through new telescopes.Tue, 05 Jun 2012 10:28:28 EDThttp://www.sciencedaily.com/releases/2012/06/120605102842.htm

Source: http://www.sciencedaily.com/rss/matter_energy/biochemistry.xml

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Video: Lab-engineered muscle implants restore function in animals

Monday, July 16, 2012

New research shows that exercise is a key step in building a muscle-like implant in the lab with the potential to repair muscle damage from injury or disease. In mice, these implants successfully prompt the regeneration and repair of damaged or lost muscle tissue, resulting in significant functional improvement.

"While the body has a capacity to repair small defects in skeletal muscle, the only option for larger defects is to surgically move muscle from one part of the body to another. This is like robbing Peter to pay Paul," said George Christ, Ph.D., a professor at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine. "Rather than moving existing muscle, our aim is to help the body grow new muscle."

In the current issue of Tissue Engineering Part A, Christ and team build on their prior work and report their second round of experiments showing that placing cells derived from muscle tissue on a strip of biocompatible material ? and then "exercising" the strip in the lab ? results in a muscle-like implant that can prompt muscle regeneration and significant functional recovery. The researchers hope the treatment can one day help patients with muscle defects ranging from cleft lip and palate to those caused by traumatic injuries or surgery.

For the study, small samples of muscle tissue from rats and mice were processed to extract cells, which were then multiplied in the lab. The cells, at a rate of 1 million per square centimeter, were placed onto strips of a natural biological material. The material, derived from pig bladder with all cells removed, is known to be compatible with the body.

Next, the strips were placed in a computer-controlled device that slowly expands and contracts ? essentially "educating" the implants on how to perform in the body. This cyclic stretching and relaxation occurred three times per minute for the first five minutes of each hour for about a week. In the current study, the scientists tried several different protocols, such as adding more cells to the strips during the exercise process.

The next step was implanting the strips in mice with about half of a large muscle in the back (latissimus dorsi) removed to create functional impairment. While the strips are "muscle-like" at the time of implantation, they are not yet functional. Implantation in the body ? sometimes referred to as "nature's incubator" ? prompts further development.

The goal of the project was to speed up the body's natural recovery process as well as prompt the development of new muscle tissue. The scientists compared four groups of mice. One group received no surgical repair. The other groups received implants prepared in one of three ways: one was not exercised before implantation, one was exercised for five to seven days, and one had extra cells added midway through the exercise process. The results showed that exercising the implants made a significant difference in both muscle development and function.

"The implant that wasn't exercised, or pre-conditioned, was able to accelerate the repair process, but recovery then stopped," said Christ. "On the other hand, when you exercise the implant, there is a more prolonged and extensive functional recovery. Through exercising the implant, you can increase both the rate and the magnitude of the recovery."

A variety of laboratory tests were used to measure results. A test of muscle force at two months, for example, showed that animals who received the implants with extra cells added had a threefold increase in absolute force compared to animals whose muscle damage was not repaired. The force-producing capacity of muscle is what determines the ability to perform everyday tasks.

"If these same results were repeated in humans, the recovery in function would clearly be considered significant," said Christ. "Within two months after implantation, the force generated by the repaired muscle is 70 percent that of native tissue, compared to 30 percent in animals that didn't receive repair."


Laboratory-engineered skeletal muscle is a potential therapy for replacing diseased or damaged muscle tissue. This computer-controlled system is designed to build properly organized muscle tissuein the lab. To do this, muscle cells are attached to strands of a natural material and are then subjected to cyclic stretching ("exercise") in a device designed to simulate the conditions of the human body. The pre-conditioning allows the cells to align in one direction, fuse to form muscle bundles, and function like normal muscle. In this video, the process is exaggerated for demonstration purposes. The process is actually much slower and involves less intense stretching.Credit: Wake Forest Baptist Medical Center

The results also showed that new muscle tissue developed both in the implant, as well as in the area where the implant and native tissue met, suggesting that the implant works by accelerating the body's natural healing response, as well as by prompting the growth of new muscle tissue.

The researchers hope to evaluate the treatment in patients who need additional surgery for cleft lip and palate, a relatively common birth defect where there is a gap in muscle tissue required for normal facial development. These children commonly undergo multiple surgeries that involve moving muscle from one location to another or stretching existing muscle tissue to cover the tissue gap. The implant used in the current research is almost exactly the size required for these surgeries.

"As a surgeon I am excited about the advances in tissue-engineered muscle repair, which have been very promising and exciting potential in the surgical correction of both functional and cosmetic deformities in cleft lip and cleft palate" said Phillip N. Freeman, M.D., D.M.D., associate professor of Oral and Maxillofacial Surgery at the University of Texas Health Science Center at Houston. "Current technology does not address the inadequate muscle volume or function that is necessary for complete correction in 20 percent to 30 percent of cases. With this innovative technology there is the potential to make significant advances in more complete corrections of cleft lip and cleft palate patients."

The technology was originally developed under the Armed Forces Institute of Regenerative Medicine (AFIRM) with funding from the Department of Defense and the National Institutes of Health. The sponsor of the current research was the Telemedicine & Advanced Technology Research Center. A longer-term goal is to use the implant ? in combination with other tissue-engineered implants and technologies being developed as part of AFIRM -- to treat the severe head and facial injuries sustained by military personnel. For example, AFIRM-sponsored projects under way to engineer bone, skin and nerve may one day be combined to make a "composite" tissue.

###

Wake Forest Baptist Medical Center: http://www.wfubmc.edu

Thanks to Wake Forest Baptist Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 53 time(s).

Source: http://www.labspaces.net/121747/Video__Lab_engineered_muscle_implants_restore_function_in_animals

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Monday 16 July 2012

Death Toll Rises from Mudslides, Flooding in Japan

Rescue operations resumed in southwestern Japan early Sunday morning, as the death toll from mudslides and flooding rose to 24, with more than 5,000 stranded.

Three days of heavy rains forced thousands to evacuate cities and villages on Kyushu, the main island in southern Japan. A record 20 inches fell on the city of Aso Saturday, collapsing 145 homes and flooding more than 800, Bloomberg News reported.

Military helicopters resumed delivery of emergency rations, clean water and medical supplies to stranded villagers in mountainous areas in Yame, Fukuoka prefecture in northern Kyushu. Rescue helicopters transported some of the elderly and injured villagers to hospitals.

At least eight villagers are still missing and 24 confirmed dead, local authorities reported. While the heavy rain eased on Sunday, meteorologists cautioned residents to be on the lookout for more rain, accompanied by strong wind and possible tornadoes.

"A peak of heavy rain in northern Kyushu has passed, but there is fear that driving rain with thunder may hit northern Kyushu," the Japan Meteorological Agency reported Sunday morning.

Source: http://www.cbn.com/cbnnews/world/2012/July/Death-Toll-Rises-from-Mudslides-Flooding-in-Japan/

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Fabricating Peacock Feathers to Make Fans - Online Gaming Tips ...


You are now at the first street of the Fan Area on your map. As the requirement to gain access on this challenge, you need to purchase the Fan factory at the shop which is worth 10000 stars. This type of structure processes your Peacock?s feather turning it into a wonderful fan which sold with a higher price as compared to the plain feather.
Requirements:

Fan Factory

Objectives:

Collect two (2) Fans

Rewards:

5000 Stars

Golden Trophy Reward with +7000 bonus stars: Complete the challenge in less than (3:30) three minutes and thirty seconds period of your time.
Silver Trophy Reward with +5000 bonus stars: Complete the challenge in less than (5:00) five minutes of your time.

Map:


Platform:
Tips:

Five cows are immediately provided by the game on this Fan Street 1 challenge. Factories had also been setup around your farm. At both side of your platform are factories which are the Separator, Butter Mill and Cheese factories. The good part about these structures is that they are all already upgraded into their highest level allowing you to process five products at the same time.

What you have to do from the start is to collect five bottles of milks before sending them into any of your two Separator factories. When it?s done, it will provide you a processed product of Sour Creams. Pick them up and send them into your Butter Mill to make some butter. While your butter is currently being processed, click on your plane and order some leavens which is an ingredient for making a cheese. At the time that you now have the leavens and collected your butters, click on your Cheese factory to make your first five cheeses.

Repeat the whole process mentioned above and spend your profit by buying your farm an additional cow. You have to buy five more cows to utilize the production of all your factories. If you manage to accomplish these tasks then earning $70 000 cash would be easy and which is what exactly you need to buy an Ostrich.

Provided that you have now the cash, buy an Ostrich and replace your Cheese factory located at the bottom right corner of the platform with a Fan factory.

Finally, collect your Ostrich feathers and make 2 fans to accomplish this level of the game.

Source: http://freeskyonlinegamestipsandguides.blogspot.com/2012/07/fabricating-peacock-feathers-to-make.html

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CTVOlympics: RT @battisctv: Finally #London gets a break from rain. Trafalgar Sq with Canada House, now under 2 weeks to @CTVOlympics @CTVNews http:/ ...

Sorry, Readability was unable to parse this page for content.

Source: http://twitter.com/CTVOlympics/statuses/224537970097664001

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F1 2012 will not support Windows XP

Codemasters has announced that F1 2012 for PC will not support Windows XP. Since the game uses DirectX 11, it?ll only support Windows Vista and Windows 7 operating systems. The developer also added that this was also the case with its most recent title, Dirt Showdown.

Although many of the hardcore gamers have moved on to Windows 7, a good chunk of the PC gaming demographic still uses Windows XP. Codemasters is yet to reveal the system requirements for the game.

F1 2012 is scheduled for release on the Xbox 360, PS3 and PC this September.

Tags: Codemasters Racing, directx 11, F1 2012, ivg, Windows XP

Source: http://feedproxy.google.com/~r/IVG/~3/LfPUpJYFxQM/

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Scott Beaver: From Losing My First Boyfriend to Homophobia to Empowering LGBT Youth: It Gets Better

Editor's note: As a part of the 2012 Fullerton High School "Mr. Fullerton" pageant, senior Kearian Giertz was asked, "Where do you see yourself in 10 years?" Kearian responded that he hoped that in 10 years marriage equality would be legal so that he could marry the man of his dreams. As a result of his answer, a school administrator disqualified him from the competition. Immediately after the incident took place, Kearian's classmates, seniors Blake Danford and Katy Hall, started a letter-writing campaign, asking the question, "Where do you see yourself in 10 years?" They added their vision of what is needed to create safe and supportive schools. Blake and Katy teamed up with the Gay and Lesbian Community Services Center of Orange County and Youth Empowered to Act (YETA). The campaign became the foundation for YETA's comprehensive, student-led program to inform students, faculty, and administrators about California's school laws, provide support and advocacy for students, and create safe schools in Orange County and beyond.

The Huffington Post is sharing the stories of several youth involved in the campaign responding to Seth's Law, which was enacted last week. For more information, and to participate in the campaign, visit Youth Empowered to Act.

* * * * *

High school is a tough time for everyone; we're all trying to figure out who we are, how to be adults, and what "clique" we fit into. This is especially difficult if you're also trying to figure out if you're gay or not.

I knew by freshman year that I was gay, but that entire year was a lie for me. I thought being gay was bad, or wrong, or maybe just a phase, and I knew I could hide it. But the pressure of all the lies was deeply upsetting, so I told my best friend. She proceeded to tell everyone else, too, to spread rumors about me. My lie was over, people knew, and I felt like everyone was staring at me. But at least I still had the support I needed to stay alive: my boyfriend.

A week after I was outed, he disappeared. I didn't know what happened to him, and I felt like my life was over. It was a few weeks later, when I was at one of the lowest points in my life, that I came into contact with one of his friends and discovered what had happened to my boyfriend. He'd come out to his parents a few months before he met me, and they'd kicked him out of his house, so he'd begun living on the streets. He'd disappeared because he'd passed away.

I felt really alone, but I reached out for help. Then I met a great friend, the absolute strongest person I have ever met. She helped get me back on track. Now I've just finished high school and am about to head to college in New York! I completed a two-year internship at the sheriff's department and actively volunteer with Youth Empowered to Act (YETA) at the Gay and Lesbian Community Services Center of Orange County.

It's so important to reach out to LGBTQ youth and let them know that they are supported and embraced for who they are. Sometimes things get low, really low, but you'll find a way out of it and get back to the top. The trick is to stand tall and stay confident. Don't let people bring you down. Ignore the bullies. Especially now, with Seth's Law in place, you are protected. If someone harasses you, you have options. Schools are now legally obligated to stop the bullies. So if you're having troubles, find the support system you can trust, and stay tough. There will be hard times, times when you'll feel like there is nowhere to go, but I can tell you with certainty that it gets better.

?

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Source: http://www.huffingtonpost.com/scott-beaver/from-losing-my-first-boyfriend-to-homophobia_b_1672557.html

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Thursday 12 July 2012

Developed or developing? Try merging markets

LONDON (Reuters) - Investors are criss-crossing the increasingly smudged line between emerging and developed markets as the euro zone crisis challenges traditional perceptions of a safe investment.

This blurring of distinctions was illustrated last month by index compiler MSCI's surprise decision to review Greece's stock market for downgrade to emerging market status, usually assigned to poorer countries offering lower liquidity and less open access to trade.

Although Greece remains a member of the euro zone, multiple credit rating downgrades, a debt restructuring, shrinking stock prices and the persistent risk it will be forced to exit the bloc and sharply devalue its currency have given it a risk profile similar to those of many developing countries.

That being so, many investors may prefer to take their chances in traditional emerging markets such as South Africa or the Philippines.

"This is a huge factor driving emerging markets -- it's obviously driven in part by the change in the risk in developed markets," said Jerome Booth, head of research at Ashmore Investment Management, which manages $66 billion (42.4 billion pounds) in emerging market assets.

"This has been happening for 15 years. It's speeded up since the financial crisis -- it's an ongoing issue but for big institutional investors, the decision to start can be followed by the actual investing only two years later."

Reflecting the increasingly broad range of investors who are seeking out emerging market investments, Booth said central banks and sovereign wealth funds made up 40 percent of Ashmore's assets under management.

Inflows into emerging market bond funds totalled $23 billion in the first half, while inflows into emerging equity funds totalled $14 billion, according to data from Boston-based fund tracker EPFR.

Meanwhile, outflows from developed Europe equity funds were $22 billion over the same period. Outflows from developed Europe debt funds totalled a smaller $1 billion, but followed a $29 billion exodus in 2011.

DEBT SWITCH

To mop up the increased demand, emerging market borrowers are likely to issue record amounts of debt -- totalling close to $300 billion -- this year.

The uncertain outlook for the euro zone, whose policymakers are struggling to convince markets they can get a grip on the sovereign debt crisis now in its third year, have pushed up borrowing costs for leading economies such as Spain and Italy.

Spain's 10-year debt is trading close to the 7 percent danger level at which other euro zone countries including Greece were forced to seek aid, while Italy's borrowing costs are nearing 6 percent. By contrast, junk-rated Turkey recently issued dollar debt at a yield of less than 6 percent.

For a core euro zone borrower like Germany, 10-year yields are puny, at less than 1.5 percent.

"The theme that has been in place for a while is to go underweight more mature developed economies such as the United States, UK and the core euro zone and use that underweight to invest in markets that have better long-term fundamentals," said Peter Wilson, managing director of First International Advisors, a subsidiary of Wells Fargo.

Wilson favours local currency debt in markets such as Mexico, South Korea, South Africa and the Czech Republic.

Whereas Greece was kicked out of global bond indices benchmarked by many investors two years ago, South Africa will join Citi's world bond index later this year.

Foreign holdings of local government bonds have nearly tripled in Mexico and nearly doubled in South Africa since 2007, according to JP Morgan.

Emerging market companies are also looking more attractive than in the past, paying higher dividends and showing stronger earnings growth.

"Companies are making better return on equity than (in) the developed world," said Laurence Taylor, portfolio specialist in global equities at T Rowe Price.

"That was not the case in emerging markets 10 years ago."

Emerging market fund managers say they have been seeing many more RFPs -- requests for proposals -- from institutional investors such as pension funds and sovereign wealth funds which are looking to start buying emerging market assets.

"It's still mandate restriction-driven -- G10 and non-G10 mandates -- but these lines are getting blurred," said Werner Gey van Pittius, who co-manages $10 billion in emerging debt at Investec.

NEW FRONTIERS

Moving further down the traditional risk profile, demand has also been huge for the small supply of new debt from so-called frontier markets.

Dollar bonds issued by West Africa's Gabon and Ghana in 2007, before the heights of the financial crisis, are trading at respective yields of 5.7 percent and 4.3 percent, well below launch levels of above 8 percent.

"Yields show African bonds are perceived to be less risky than some of the European ones right now," Ravi Bhatia, sovereign ratings analyst at Standard & Poor's, told a briefing last week. "A lot of people are trying to get out of Europe and into emerging market assets."

Emerging markets still carry their own risks, however, not least because as they become more sophisticated, their trade, banks and market prices are increasingly linked to the rest of the globe. Emerging stocks <.mscief> fell more than 20 percent last year and the giant BRIC economies - Brazil, Russia, India and China - are starting to falter.

"We see risks as being connected," said Percival Stanion, who runs a 9.7 billion pound multi-asset strategy at Barings Investment Management.

"We are wary about the euro zone, and this is reflected in our wariness about other risk assets -- emerging markets are obviously a high risk area."

But for those who really want to take a punt, there is always the opportunity to go the other way.

Broker Exotix, which specialises in frontier debt, started covering Greek, Portuguese and Cypriot debt this year, and recommends buying Greece's restructured bonds.

As Greece does not feature in any emerging debt indices, some specialist fund managers may be constrained by their mandates from buying it, but it is starting to appeal to risk-loving investors.

"A lot of ... emerging market-type hedge funds invest in Greek bonds today," said Julian Adams, CEO of London-based hedge fund firm Adelante Asset Management. "It's taken a while for the mentality to shift."

(Additional reporting by Sujata Rao and Laurence Fletcher; Editing by Catherine Evans)

Source: http://news.yahoo.com/developed-developing-try-merging-markets-123130180--finance.html

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Wednesday 11 July 2012

NetSpot (for Mac)

We've come to depend on Wi-Fi as a way to work and play on our phones, tablets, laptops, desktops, home video game consoles, and a myriad other products. As such, it's important to have a strong, dependable signal to transfer data. NetSpot, a free Mac utility from Etwok, lets you scan your immediate area for Wi-Fi signals and view related information such as open and closed signals, dead zones, and more. More importantly, NetSpot has a drawing tool that lets you map a Wi-Fi-friendly floor plan in your home or office, so that you can arrange your router and electronics in such as fashion that you'll receive strong throughput.

The NetSpot Experience
NetSpot is used in one of two ways: as a simple Wi-Fi detector (with color-coded readouts in the left column) or as an advanced tool for arranging your router and hardware to create the strongest network possible. When I fired up NetSpot, it quickly picked up dozens of signals (both in the PCMag.com lab and beyond), and identified the strength of each, whether or not they were open or password-protected, SSID, and more.

If you want to see where the signals are the strongest and weakest within your immediate vicinity, NetSpot can help with that, too. When you click a spot on the screen (which can either be a blank or populated with a generic floor plan), NetSpot scans the area for available wireless networks. NetSpot then prompts you to walk around the area while carrying your laptop so that you can see the various strengths in different areas of the room. As such, this mapping feature isn't very useful to desktop computer users.

That said, I like that you can even add measurement information so that you can draw floor plans to scale?very cool. Once you identify the dead points in your home or office (and their sizes) you can remedy the problem by physically relocating your router or purchasing a repeater to give your wireless signal a boost.

Net-worthy
NetSpot is a powerful free app that serves up a surprising amount of relevant Wi-Fi data, and a no-brainer Editors' Choice winner. Desktop users may not take advantage of the mapping feature due to their computers' relative immobility, but laptop users who have even the faintest interest in the surrounding wireless networks should download this app.

More Utilities Reviews:
??? Think (for Mac)
??? NetSpot (for Mac)
??? Caffeine (for Mac)
??? Focus Booster (for Mac)
??? Afloat (for Mac)
?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/gYS1jMglr9U/0,2817,2406897,00.asp

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Tuesday 10 July 2012

iHeartRadio fest to star Lil Wayne, Bon Jovi, more

FILE - This April 24, 2012 file photo shows singer Rihanna attending the TIME 100 gala, celebrating the 100 most influential people in the world, at the Frederick P. Rose Hall in New York. Rihanna has sued her former accountants in New York, blaming them for tens of millions of dollars in losses. The lawsuit was filed Thursday, July 5, in federal court in Manhattan. It seeks unspecified damages against New York based Berdon LLP and two accountants. A Berdon spokeswoman says the company has no immediate comment. (AP Photo/Evan Agostini, file)

FILE - This April 24, 2012 file photo shows singer Rihanna attending the TIME 100 gala, celebrating the 100 most influential people in the world, at the Frederick P. Rose Hall in New York. Rihanna has sued her former accountants in New York, blaming them for tens of millions of dollars in losses. The lawsuit was filed Thursday, July 5, in federal court in Manhattan. It seeks unspecified damages against New York based Berdon LLP and two accountants. A Berdon spokeswoman says the company has no immediate comment. (AP Photo/Evan Agostini, file)

(AP) ? Taylor Swift, Aerosmith, Rihanna, Usher, Bon Jovi, Lil Wayne, Green Day, Miranda Lambert, Mary J. Blige, Shakira and others are set to take the stage at the iHeartRadio Music Festival 2012 this fall in Las Vegas.

The stellar lineup suggests the two-day marketing blitz to promote Clear Channel's iHeartRadio digital music service is on its way to repeating the success of last year's debut concert.

Clear Channel, which also owns 850 terrestrial radio stations in the U.S., says Brad Paisley, Pitbull, Enrique Iglesias, No Doubt, Linkin Park, Jason Aldean, P!nk, deadmau5, Swedish House Mafia and Calvin Harris are also among the performers set for the festival on Sept. 21 and 22 at the MGM Grand. Ryan Seacrest will introduce the first night's show.

"Last year's iHeartRadio Music Festival had so many acts from so many different genres on one stage, a true rarity for a concert," Seacrest told The Associated Press Monday. "This year it's set to be bigger and better, with an unbelievable roster of some of the most talented names in the music business."

The lineup of performers reflects the diversity of artists on the digital music service, said the event's executive producer Tom Poleman.

"The cool thing about iHeartRadio is it's multiple genres of radio stations on one platform," he said. "It's cool when you can then translate that to a live event like the iHeartRadio Music Festival. It's fun to look around the audience and see, they may not have been into Brad Paisley when they got here, but suddenly the Rihanna fan becomes a country fan."

Last year's inaugural iHeartRadio concert featured Jay-Z, Coldplay, Alicia Keys, Carrie Underwood, Steven Tyler, Rascal Flatts, Nicki Minaj and Lady Gaga, among others.

The concert will play live on iHeartRadio.com and Clear Channel stations nationwide, Poleman said. Video of some performances will also be available through a partnership with Yahoo, he said, adding that Clear Channel plans to make the two-day, all-star show an annual event.

Tickets for the iHeartRadio Music Festival 2012 go on sale July 14.

___

Online:

www.iHeartRadio.com/vegas

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-07-09-Music-iHeartRadio-Festival%20Lineup/id-7ae4abdae9cc4079970d291ad8c1d575

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Engadget Mobile Podcast 145 - 07.09.2012

A sub-90-minute Engadget Mobile Podcast is a rare breed, and a sub-90-minute Engadget Mobile Podcast with Joseph Volpe is a sighting of albino liger proportions. Take in this breath of fresh air, tinged with the sweet confectionist scents coming down from the Mountain View and the smell of money their distributors and competitors are either making or losing in other areas of the universe.

Hosts: Myriam Joire (tnkgrl), Brad Molen
Guest: Joseph Volpe
Producer: Trent Wolbe
Music: Tycho - Coastal Brake (Ghostly International)

00:27:10 - Motorola ICS UI review: this isn't the Blur we used to know
00:51:49 - Samsung denied: Judge Koh declines to lift injunction against Galaxy Nexus, but Google's got a workaround
00:58:52 - RIM's Thorsten Heins denies company's 'death spiral,' predicts successful transition to BlackBerry 10
01:04:38 - Motorola Atrix HD revealed with 4.5-inch Colorboost HD display, ICS and Droid RAZR looks
01:12:13 - HTC reveals Q2 2012 financial results: 57.8 percent net profit drop blamed on customs issues and weak sales
01:15:45 - Bloomberg: Amazon is planning a smartphone

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Engadget Mobile Podcast 145 - 07.09.2012 originally appeared on Engadget on Mon, 09 Jul 2012 16:48:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/07/09/engadget-mobile-podcast-145-07-09-2012/

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Sunday 8 July 2012

He Dreams in Red (Feedback A-Okay)

Thing that I entered a few years ago, thought I'd throw it up here.

Feedback is always welcome.

----

The quiet of the hospital room was offsetting, a myriad of whirs and clicks occasionally breaking through the stony silence, and yet they didn't disturb his sleep. Stretched out on the bed, his long legs just barely fitting onto the crisp white hospital sheets, was my father, lying in a deep slumber. It was no mystery what thoughts raced through his head at that point; my father was dreaming. Dreaming in red.

It was a very interesting moment in my life when I realized that my father not only loved the color red as if it were his own flesh and blood, but he dreamed it, too. I was a mere boy of six years old, standing with my father's large hands on my shoulder as we both watched my mother, a beautiful Korean girl with green eyes and a large face, go through her final breaths in this word. My father was swaying, drunk, his hands clenching and unclenching in the fabric of my shirt. He cried, I didn't. When it was all over, he whirled me around, and when we were eye to eye, he spoke.

?Look at that woman, son. Such a delicate creature. It's a shame she left me you.?

Thus began my relationship with my father.

You have to understand; the color red has very little to do with his dreams. Red is a means to an end; a symbol I use in place of a thousand other words that describe the pictures that fill his head when he sleeps. No, Red very rarely attaches itself to my father, but everything red stands for shows up often.

Red is the color of vengeance, passion, love, betrayal, and any number of other encompassing rituals that involve bloodshed or murder. My father loved these themes. He went to bed every night reading about them ? fictional or otherwise- and in the morning he'd shove my nose in a book, tell me about a character, and demand to know why I wasn't more like them. He'd show me Sarumon and the Ice Queen; he'd show me Sirius and Huck Finn and Lysander. Each time he'd say the same thing. ?Be more like them, son! Why can't you be more like them??

The beatings that followed were, of course, a small ritual that also attached itself to the color red. Red my cheeks would be, from his hand or his belt, or when he was drunk enough, the large fire poker. Red was his face, contorted in rage over simplistic things, like his son not being a warlord or a wizard.

The beating and drinking peaked when I was nine years old, around the same time my father met a woman. She never told me her name, but she was what people referred to as a gold digger. At the time, I called her Goldie, and was confused by the term. Prospectors and gold diggers were always bearded, with fewer teeth than gaps in their mouths and a raucous cough that irritated the senses. Goldie was the most beautiful woman I've ever seen, and I often told her so.

My father would backhand me when I spoke to Goldie, telling me that I wasn't good enough for her. ?She's an angel; a goddess. You're a runt. Eat your dinner, son.? He'd follow the insult with a shove at the base of my skull, sending my face towards my plate. After some time, I ate in silence. Goldie, however, looked at me with sympathy and raw compassion that made me want to cry.

I usually lay awake at night, imagining her perfect voice and body sleeping beside me, comforting me, sending her long, piano playing fingers through my hair. Little did I know that across the hall, she was doing much the same to my father. He needed comfort almost as badly as his abused and malnourished son did, and I loathed him for it.

When I was eleven, Goldie left us. She left us when my father lost his job for being too drunk a time too many. She never spoke a word to me, just disappeared when my father was out begging for his job back. She left, and I watched her leave.

When my father came home, he was crying, and immediately started yelling at me, blaming his eleven year old boy for, once again, causing all of his problems. ?Why'd you let her leave, son? Why'd you let her go!??

After Goldie left, there was nothing tying me to the house and the man who owned it. I packed a bag that night, and a month later I left, getting a job at a warehouse a mile down the road. My father and I rarely saw each other until my fifteenth birthday, when I began to lean on alcohol just as heavily as he once did. We drank together that day, without saying a word.

Our paths crossed little that year, the year when we were both drunk so often that we were mistaken for brothers. I had aged beyond my years, a thick beard covering my face even at fifteen, and he had still retained the youth and vigilance of a thirty year old, albeit with a ruined liver. Occasionally we sat together and discussed life, girls, and how we were doing. Occasionally we griped about our jobs. Occasionally we fought.

The fights would last through the night, with him always the victor because I was simply too weak to fight back. Despite the fact that I was growing stronger with each day at the warehouse, he was much bigger and stronger than I. Even when I had the upper hand, I was always compelled to stop, pitying this man, this oafish beast who dreamed while awake, dreamed in such a vivid red that everything else faded away into nothing.

Whenever the fight ended, and he stood with a boot on my chest, he'd grin at me. ?You can't even beat up an old man, son. You're still worthless.?

He would then stumble away to spend another evening in the drunk tank, and I'd brush myself off and go home to my temporary house, which I shared with two brothers and their sister, a ravishing young lady named Rebecca. I'd unlock the door, throw the keys on the counter, and sit down on the leather chair. I'd sit there until morning, wondering who I had become.

The year I turned seventeen was magical; I decided to turn my life around and put my father behind me, for good. My form was tall and still lanky, but I had worked hard enough to afford a small apartment in a corner building, where I had a view of the London bridge. After some contemplation, I invited my former house mates to join me, as the rent was costly. Only Rebecca made the move.

My seventeenth year was a grand one. My job was well, my pockets were lined, and I had shelter. But memory is a fickle mistress; despite my achievements, I always revisited the thirteen years of my seventeen that I had spent under the heel of a red-obsessed tyrant. I was ready to move on, to explore, to get out on my own.

At least, I thought I was ready, until I ran into Goldie again whilst shopping for food. We had stared at one another for a good while before she broke into a smile, and trailed her fingers down my shirt sleeve in what I imagine was supposed to be a seductive way. I was wearing new pants, a new jacket, and looked like the man I was; financially secure.

She was wearing a ruby ring, the blood red of the stone glinting in the light from the store's bulbs, and I had been jarred into so many memories, memories of thirteen years of violence and cruelty in my own home. No schooling, no friends, just a slow burn, a tortuous pain that began ? and ended ? in a vibrant color that haunted both of our dreams.

I am not ashamed to say that I ran from that store. I ran like the hounds of hell themselves were chasing me, nipping at my heels. I ran into my apartment, grabbed a pencil and a piece of paper, and went to find Rebecca.

She was working at her family?s law firm, busily scratching down names and places and dates, hurriedly trying to move her business along. I marched over to her, dropped the paper and pencil in front of her, and leaned across her desk, until her eyes filled my vision.

?Teach me.? I said. She smiled at me, slowly, and that slow smile did more for my nerves than Goldie's caresses did, or ever would.

That night, I sat Rebecca down, put her feet on my lap, and told her. I told her about my father. I told her about the man who lives and breathes Red. When my story was done, our embrace was passionate, and the color red appealed to me in ways I never thought possible.

Two years later, when I was nineteen and Rebecca was eighteen and we were happily together, I met my father again, for the first time in years. He was drunk, per usual, but what wasn't normal for my father was the two little girls, barely dressed, pressed to his waist with two meaty hands. The smile he wore made my toes curl and my fingernails dig into my palms.

My father wheeled them around to stare at me, and let out another raucous laugh. ?Look, son. These girls are just like you. They'll never amount to nothing.?

My fist swung before I even knew what was happening, and the two girls were suddenly screaming as my father hit the pavement, the sound of stones and skull filling the air. Their screams stopped when I knelt down, my fist a machine, pumping back and forth, smashing the ugly, drunken bastard's face over and over and over, the rhythm becoming almost second nature, a sad tune without lyrics, a rhythm section without a melody.

When I could stand, I left the girls with an orphanage, and left my father in the street. His face now matched his dreams, a red splotch in a gray blacktop. He didn't come out of a hospital for three days, and when he did he went straight to my apartment. I told Rebecca not to come out if she heard shouting or fighting, and went to let him in.

I was still the skinny teenager, and he was still the large brutish man who couldn?t tell reality from the dream world. He won the fight. Afterwards, while Rebecca nursed my wounds and stroked my hair, I felt centered, content. As we lay there in intimate embrace, I spoke the muffled words against her collar, the best words I'd ever say in my entire life.

?Let's get married.?

It was not a question, and she responded as such. ?Okay.?

The matter dealt with, we both drifted off.

I was twenty-one before we raised enough funds for a large wedding. In the two years we were saving up, I met her family multiple times, and she had met mine more than enough to last a lifetime. Her father, mother, three brothers and millions of cousins were all invited to the wedding. I had only one guest to inform, and I visited him on a stormy night in July.

My father lived in an old shack in the middle of a rural area. He didn't do much entertaining because he was a shut-in, a man who was best left alone to his dreams and nightmares, his reds and ambers. I knocked on the door, and he answered. ?You look bigger, son. You've been toughening up.?

?I'm getting married, Dad.? I said, the term alien to my mouth and equally so to his ears. ?I'm getting married on Sunday, in a church, to a beautiful woman.?

He looked mildly confused. ?You expecting me to come??

I shrugged one shoulder. ?No, I'm expecting you not to. In fact, please don't.?

He slammed the door as soon as the words left my lips, and I walked away, my past shut behind me just as violently.

It was ten years before I heard from my father again, long after I had moved my family to Canada, long after the birth of my youngest daughter, Charisse. Michael was four when she was born, and it made us complete; a family of four. I received a call from a doctor in England, telling me that my father was ill, dying, and that he wanted to see me.

After all this time, after the hate and loathing and anger, I caught a red eye to London, spending the entire time on the plane alternating between nervous, worried, and determined. I was finally going to get some answers from him. I was finally going to find out why.

He said a single thing when I arrived. ?It's about time you showed up, son. You were a right pain in the ass, you were. Never even loved me, did you??

He was snoring when I noticed the cord. It was fat and thick, deep, blood red. It ran between the machine and my father's breathing mask, the only thing keeping him here. That fat, red cord.

My fingers wrapped around the red cord that attached my father to his machine, the machine that was breathing life into him with every labored pump. I thought long and hard about Goldie, Rebecca, fighting, drinking, Charisse, Micheal, and especially of my father. I remember everyone who broke him, and everyone who healed me, and everyone who had nothing to do with either of us but certainly played a large part in the world. I thought about my options, whether or not I would end the vivid dreaming session my father no doubt was going through, the color that haunted him suddenly swimming through his veins, the anger, the hate washing over him until he could see no more, hear no more. Breathe no more. I thought about all of this and more while running my fingers across that damned red cord, feeling its weight, the power I held while my father lay, battered and broken, upon those crisp white sheets. I thought about it all, and then I gave the lightest amount of pressure, feeling the cord slip slightly out of its outlet, hearing my father's breathing grow heavier, steadier.

He dreamed in Red, but the world didn't dream with him.

I pulled.

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/dOH816qc3zg/viewtopic.php

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